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KMID : 0978920120130040203
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Korean Journal of Clinical Geriatrics
2012 Volume.13 No. 4 p.203 ~ p.208
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Clinical Value of Homocysteine in Peripheral Neuropathy Associated with Parkinson’s Disease and Diabetes Mellitus
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Choi Hyun-Ah
Kim Young-Do
Cho Hyun-Ji
Song In-Uk
Chung Sung-Woo
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Abstract
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Background: Peripheral neuropathy (PN) has been described in significantly higher proportions in patients with Parkinson’s disease (PD) or diabetes mellitus (DM) than in healthy controls. However, pathophysiological mechanisms underlying the development of PN are not well understood. It is currently thought that hyperhomocysteinaemia may induce endothelial dysfunction through increasing oxidative stress. It is not known if hyperhomocysteinemia is associated with PN and may thus be a contributing factor in the pathogenesis of PN. In view of these considerations, we investigated to clarify relationship between hyperhomocysteinemia and PN with PD or DM and to assess difference between the role of homocysteine in PN with PD and DM.
Methods: We recruited 31 PD with PN, 36 type 2 DM with PN and 43 healthy controls. All subjects underwent electrophysiological test to clarify presence of PN and subjects with PD were evaluated the motor severity by using modified Hoehn and Yahr Stage. We analyzed correlation between plasma homocysteine level and neuropathy with PD or DM.
Results: Plasma homocysteine levels in patients with PN showed higher plasma concentration than those in healthy controls. Interestingly, this study also demonstratedsignificant higher plasma homocysteine concentration in PN with PD than those in PN with DM.
Conclusion: The present study showed that hyperhomosyteinemia might play a role in risk factor of PN in patients with PD and DM. Moreover, we could also suggest that increased plasma homocysteine concentration may contribute to the pathogenesis of PD because PN patients with PD have higher plasma homocysteine concentration than those with DM.
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KEYWORD
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Homocysteine, Neuropathy, Parkinson’s disease, Diabetes mellitus
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